EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

DESIGN, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF N-PHENYLACETYLAMIDO DERIVATIVES OF HETEROCYCLIC COMPOUNDS

Ghadge Ojaswi*, Nadar Divya, Parmar Digna and Mahajan S. S.

ABSTRACT

Microbial infections pose a continuing and serious threat to human health. The intrinsic resistance has been observed in many genera of bacteria and fungi. Many infections are caused by opportunistic pathogens that may be endogenous. So, new chemical entities are needed to combat various microbial infections. In the present study, design, synthesis and evaluation of antibacterial and antifungal activities of simple N-phenylacetylamide derivatives of benzothiazole/ benzimidazole/ morpholine moieties are reported. Design of antibacterial and antifungal activities was carried out by performing docking studies using Glide module of the molecular modelling software Maestro 10.5 from Schrödinger, USA. A cubing receptor grid was centered around the co-crystallized ligand. Validation of ligands was carried out by dedocking and redocking the inhibitor. The SP (standard precision) scoring function was used. The compounds showing good G-scores were synthesized and their structures were confirmed by physical and spectral studies. The synthesized compounds were screened for antibacterial activity against Staphylococcus aureus and Escherichia coli and for antifungal activity against Aspergillus niger. Synthesized compounds exhibited significant antimicrobial activity and can certainly hold greater promise in discovering new antimicrobial entities.

Keywords: Benzothiazole, benzimidazole, morpholine, antimicrobial activity, molecular docking.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)