EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

SERUM LIPID PROFILE IN DISTINCT GRADES OF SUBCLINICAL HYPOTHYROIDISM

V. Ramesh*, R. Kamalam and C. Gandhimathi

ABSTRACT

Dyslipidemia is the most common metabolic abnormality in subjects with thyroid disease, either in overt or subclinical forms of disease. Association of overt Hypothyroidism with abnormal lipid profile is the accepted clinical finding but still there is a skepticism regarding subclinical hypothyroidism (SCH) associated with lipid disorder. The purpose of the present study was to explore the association between thyroid hormones and abnormal lipid profile in SCH. 342 study subjects in the age group of 15 to 80 years were analysed. In this, 230 were Euthyroid Controls, 112 subjects were having SCH (60 persons were having Grade - I SCH, TSH < 6 μIU/ml; 40 persons - Grade II SCH, TSH 12 μIU/ml). The thyroid profile namely Serum TSH, free thyroxine (FT4) and the lipid profile namely serum TGL, Total cholesterol, HDL cholesterol and LDL cholesterol were measured. Serum TGL, LDL, Total cholesterol, Total Cholesterol/HDL ratio levels in SCH individuals were significantly higher than euthyroid subjects (p<0.01). No statistically significant difference between SCH individuals and euthyroid controls were found in HDL level except for an increase in HDL levels. It is also observed that the percentage of elevated serum lipids in the study subjects were more marked in Grade III SCH than the other groups. Hence, the present study supported the fact that hypothyroidism was associated with an abnormal lipid profile especially with respect to the levels of Total cholesterol, LDL and triglycerides.

Keywords: Subclinical Hypothyroidism, TSH, Lipid Profile, Dyslipidemia.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)