EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTIHYPERGLYCAEMIC ACTIVITY OF SCLEROCARYA BIRREA IN RATS

Z. P. Deh, D. P. Koffi* and G. F. Monteomo

ABSTRACT

The trunk bark of Sclerocarya birrea (Anacardiaceae) traditionally used for the treatment of diabetes Côte d'Ivoire, have been purchased from herbalists in Abidjan. The decoction of Aqueous extract of Sclerocarya birrea (AESB) was administrated orally in the hyperglycemic rats fasting single and repeated taken at the respective doses of 35 mg/kg and 7350mg/kg. Hyperglycemia was induced by oral glucose load with the dose 4g/kg. The result after 2 hours of these EASB doses showed to hyperglycaemic rats greater antihyperglycaemic share of 30% (p<0,05; n= 8) in single and 20% in repeat doses. Sclerocarya birrea extract at 35mg/kg remained active for 4 times as single administration and after 2 days repeated administration with reductions in blood sugar levels, respectively 40% and 38% in hyperglycaemic rats made In conclusion, the administration of low dose (35 mg/kg) of AESB leading to the hypoglycaemic activity in animals given a glucose load orally. These results confirm the therapeutic indication of Sclerocarya birrea concerning its antidiabetic activity in the treatment of diabetes disease in traditional medicine.

Keywords: Sclerocarya birrea, Diabetes, Antihyperglycaemic activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)