An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57



Ukwueze S. E.*, Nwachukwu I. P. and Ezealisiji K. M.


The aim of this study was to carry out a spectrophotometric and other pharmaceutical quality evaluation of different brands of azithromycin dihydrate tablets and capsules from Nigerian markets and to predict their bioequivalence using in vitro dissolution tests. The evaluation was done by carrying out tests such as weight uniformity, friability, active drug content, disintegration and dissolution tests using standard procedures. The similarity factor was determined for the brands. All the brands complied with the weight uniformity test, friability (brands AZ1-AZ9) and active drug content test. All brands (except AZ8) complied with the official specification for disintegration time test with no disintegration at T30 and dissolution test with T30 less than 85%. With dissolution profile of 85% within 15 minutes for samples AZ1. AZ8 displayed very low dissolution rate, which would likely result in poor bioavailability. From the results of the bioequivalence determination, all the tested brands (except AZ-8) could be said to be bioequivalent with the innovator brand (AZ9) and thus interchangeable. The similarity factor (F2) value for sample AZ8 was determined to be 10.7, suggesting that (AZ8) was not bioequivalent with the innovator product as its F2 value fell outside the acceptable standard. In conclusion, the results of the study showed that there is the need for constant monitoring of different brands of azithromycin introduced into the drug market to ascertain bioequivalence and conformity with pharmacopoeia standards.

Keywords: Azithromycin dihydrate, Tablets, Capsules, Comparative study, Bioequivalence.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)