EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EFFECT OF EXCIPIENTS ON THE RELEASE OF TRIMETAZIDINE DIHYDROCHLORIDE FROM BIODEGRADABLE POLYMERIC IMPLANTS

Khadiza Mousumi Talukdar, Rifat Ara Islam, Amer Khorshed Alam, Rajia Sultana and Swarnali Islam*

ABSTRACT

The purpose of this research was to evaluate the prospect of fabrication of biodegradable implants with Trimetazidine dihydrochloride which plays an important role in prophylactic treatment of angina pectoris, ischemia, tinnitus and Meniere’s disease to achieve prolonged release of the drug in order to reduce the dosing frequency as compared to the conventional dosage form. Drug loaded implants with Chitosan and Sodium Alginate were prepared in two varying ratios of 60:40 and 70:30. As the 70:30 Chitosan-Sodium Alginate implants with 25 mg drug load produced the maximum sustained action, this formulation was explored for further development using different excipients. The implants were evaluated for loading efficiency and in-vitro drug release profiles. The results of in-vitro dissolution study were fitted into Zero order, First order, Higuchi and Korsmeyer-Peppas kinetics to elucidate the drug release mechanism. Implants were found to follow Korsmeyer-Peppas model. Also good correlations were obtained with Higuchi model. According to these models, the drug release from the implants was diffusion controlled, where the drug leaving the matrix through pores and channels formed by the entry of dissolution medium.

Keywords: Biodegradable Polymeric Implant, Chitosan, Sodium Alginate, Trimetazidine dihydrochloride.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)