EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EVALUATION OF ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACTION OF LEAVES OF RHINACANTHUS NASUTUS (L.)

Suresh V.*, Senthilkumar N., Ganesh Kumar T., Yuva Srinivas G., Varadharajan V., Tamilselvan A., Vasu Devan P.

ABSTRACT

Objective: To evaluate the antidiabetic effects of ethanolic extracts of Rhinacanthus nasutus leaves (ERN) in Wister rats. Methods: Alloxan induced diabetic test model were performed to evaluate antidiabetic activity of ERN at two different doses 200 and 400 mg/kg respectively. Ethanolic extract of Rhinacanthus nasutus leaves (Acanthaceae) was tested for anti-diabetic activity for alloxan induced diabetics in wistar rats. After oral administration of the extract at two different doses (200 and 400mg/kg body weight) for 21 days to alloxan-induced diabetic rats, the blood glucose, level was assayed periodically on 0, 7, 14 and 21th day. After 21 days treatment all biochemical parameters like total cholesterol, triglyceride, total protein levels were checked and compare with control and standard group and body weight was also determine which was compare with initial weight. Results: Ethanolic extract shown significant protection and lowered induced blood glucose level to normal in glucose tolerance test on the day 0,7, 14 and 21th compare with diabetic control and standard groups. There was significant control of all biochemical parameters levels like total cholesterol, triglyceride, total protein in extracts of Rhinacanthus nasutus leaves treated diabetic rats. Marked body weight loss was observed in diabetic rats. The data obtained from this study showed that the treatment of extracts Rhinacanthus nasutus leaves protect the diabetic rats from loss of massive body. Conclusions: These results indicate that the Rhinacanthus nasutus leaves posses significant anti-diabetic activity.

Keywords: Antidiabetic activity, Rhinacanthus nasutus, Acanthaceae, Alloxan- induced diabetis, biochemical parameters.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)