An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57



Dr. Sohini Sengupta Neogi*, Dr. Dharma Choudhary and Dr. Raj Kumar Kapoor


The calcineurin inhibitors (CNI) cyclosporine and tacrolimus are widely used as immunosuppressive agents in recipients of hematopoietic stem cell transplantation. Since limited data is available from India on this subject, the objective of this study was to retrospectively evaluate the impact of CNIs on the post-transplant level of serum magnesium, potassium and creatinine and compare the toxicity profile of the two commonly used CNIs cyclosporine and tacrolimus. We observed that 20/31 (64.5%), 15/31 (48.3%) and 8/31 (25.8%) patients had low magnesium, potassium and high creatinine respectively. At a 5% level of significance, serum magnesium showed a significant decline over a three week period in patients on cyclosporine (p value:0.017). The dosage of cyclosporine also correlated significantly with the maximum decrease in serum magnesium in the third week post-transplant (r: -0.620, p value: 0.014). We concluded that ionic imbalance is an important side-effect of CNIs and regular estimation of electrolytes is imperative for early detection of abnormal levels. Periodic evaluation of magnesium as an integral part of the diagnostic protocol in the immediate post transplant period particularly assumes greater significance. Appropriate correction of electrolyte imbalance would help prevent multiple co-morbid conditions.

Keywords: Calcineurin inhibitors, haematopoetic stem cell transplant, magnesium, potassium, creatinine.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)