EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

5, 5'-TETRA HYDRO-1H, 3H-FURO [3, 4-c] FURAN-1,4-DIYLBIS (2-CHLORO-1, 3-BENZODIOXOLE, SESAMINE DERIVATIVE, NEUTRITIVE IN LOWERING HYPERGLYCEMIA

U. V. Sharmila*, Ashish Kumar Sharma and Gaurav Sharma

ABSTRACT

Recently, studies have reported that sesame oil lowered blood pressure and improved antioxidant status in hypertensive and diabetic-hypertensive patients. This study was to evaluate the effectiveness of synthetic sesamine derivative (3-o-methyl-d-glucose) in normal and alloxan induced rats. The study included 30 Wistar strain albino rats and randomly divided into 5 equal groups, normal rats (Only fed with normal rat feed), alloxan monohydrate 150mg/kg BW rats, sesamin derivative 10mg/kg BW, alloxan monohydrate 150mg/kg BW rats+ sesamin derivative 10mg/kg BW, Alloxan monohydrate, reference control i.e., Standard drug Glibenclamide 10 mg/kg BW was administered for 28 days for various biochemical analysis. The induction of diabetes has caused significant initial increase in the fasting blood glucose levels of all the groups. The diabetic control group shows significant increase throughout the study period when compared with the normal control group (p<0.001). However, the extract treated groups and the standard treated group shows significant decrease in the fasting blood glucose levels when compared with diabetic control (p<0.001) which was determined on the 7th and 14th day of experiment. SGOT, SGPT and ALP, show significantly lower levels of SGOT, SGPT and ALP in comparison to the diabetic control group (p<0.001). Fat accumulation in liver and inflammation were reduced with sesamine derivative. Sesamine derivative can provide a safe and effective option that may be useful in clinical practice to lower hyperglymia.

Keywords: Diabetes, Alloxan monohydrate, Glibenclamide, ALP.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)