EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A STUDY ON PHARMACOVIGILANCE IN GENERAL MEDICINE DEPARTMENT OF BANARAS HINDU UNIVERSITY HOSPITAL VARANASI

Dinesh Kumar*, B. L. Pandey, Dhiraj Kishore and Ashok Kumar

ABSTRACT

Introduction: Research on Pharmacovigilance can increase our understanding about any response to a drug which is noxious and unintended which occur at normal doses of a drug used in human beings for therapy, diagnosis. Adverse drug reactions are considered as one among the leading causes of morbidity and mortality which can affect most organ system. Several contributing factors for adverse drug reactions are polypharmacy, age, dose and duration. It describe about drugs that are most frequently showing adverse drug reactions during the hospital stay and also explain about the organ systems mostly effected due to adverse drug reaction of drug. Objective: To study and evaluate patterns and profile of adverse n drug reactions at our general medicine department of Banaras Hindu University Hospital and assess the impact of passive surveillance of adverse drug reaction (ADRs) reporting. Patients and Methods: It was a prospective observational study done from June 2014 to December 2018 in 110 patients with ADRs in the general medicine department of university hospital, Banaras Hindu University. The clinical pattern, spectrum of ADRs reported and assessment of ADRs in terms of causality, severity and preventability .The causality, severity and preventability assessment was done on the basis of applying various scales for each of them. Results and Discusions: A total of 110 suspected ADRs were reported and evaluated in the department. Dermatological system (32%) was most commonly involved. Drug class most commonly associated was Antimicrobials (47%). 58% ADRs were classified as “Probable” in view of causality, while 48% were found to be “Moderate” in case of severity. In 71% of the cases the ADRs was “Probably Preventable”. In majority of the cases the suspected drug was withdrawn and alternate therapy was instituted. Most patients recovered from the ADR.76% of these ADR was Type A. Conclusion: Awareness about ADR reporting is still poor amongst healthcare professionals in India. Conducting regular training programmes can improve the number of ADR reporting.

Keywords: Pharmacovigilance, Adverse drug reactions, Banaras Hindu University, General Medicine, Causality.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia