An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57



Tasnim Sultana, Dipankar Chandra Roy and Mohammed Rahmatullah*


The objective of the present study was to determine the antihyperglycemic effects of methanol extract of Stemona tuberosa roots in glucose-challenged mice. This is a part of our ongoing anti-diabetic project to identify antihyperglycemic local plant species. Antihyperglycemic activity was determined through oral glucose tolerance test (OGTT) in mice. Administration of methanol extract of Stemona tuberosa root (MEST) at doses of 50, 100, 200, and 400 mg per kg body weight each to glucose-loaded mice reduced blood glucose levels by 12.9, 30.7, 33.8, and 39.7%, respectively compared to control (untreated) mice. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 40.8%. Conclusion. Methanolic extract of roots of Stemona tuberosa can improve oral glucose tolerance and thus is effective in lowering elevated blood glucose levels, which at the highest dose tested was comparable to glibenclamide.

Keywords: Antihyperglycemic, Stemona tuberosa, glibenclamide, OGTT.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)