EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTIBACTERIAL ACTIVITY OF SKIN SECRETION AND ITS EXTRACTION FROM THE TOAD Bufo melanostictus

K. Thirupathi, G. Chandrakala, L. Krishna, T. Bheem Rao and Dr. Y. Venkaiah*

ABSTRACT

Skin secretion of Amphibians generally contain multiple antimicrobial peptides with distinct spectra of activity and it has been speculated that the animal is protected from invasion by a wide array of different microorganisms. The objective of the present study was to assess the antimicrobial properties of skin secretion and its extract from Indian toad Bufo melanostictus (Schneider). The collected skin secretion was filter-sterilized, freeze-dried and subjected to antibacterial assay. Antibacterial activity of toad skin secretion was tested on Asthana Hawkers agar medium plates seeded with the species of Escherichia coli, Staphylococcus aureus, Proteus vulgaris and Klebseilla pneumoniae through well diffusion technique by using Zone of inhibition (ZOI) method. An inhibition was observed with 40μl/ml of frog skin secretion. Results showed that the skin secretion of toad has antibacterial activity against four strains. All the skin secretion and extraction have showed nearest inhibition zones i.e., viz., 30mm, 27mm, 28mm,33mm,19mm, 24mm, 19mm and 25mm.Hence,we conclude that the skin secretion and extract can be employed in the development of potent antibacterial agents used to treat infectious diseases.

Keywords: Skin secretion, Asthana Hawkers agar medium, Zone of inhibition, Escherichia coli, Staphylococcus aureus, Proteus vulgaris, Klebseilla pneumoniae.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)