EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

SCREENING AND SELECTION OF SURFACTANTS FOR SOLUBILIZATION OF TRAVOPROST USING DESIGN OF EXPERIMENTS

*Sapna Ramesh Pujari, Kavita Inamdar and Supriya S. Mahajan

ABSTRACT

Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension. The current marketed formulation of Travoprost 0.004% in the US (Travatan Z) is a micellar solution with an ionically buffered preservative system Sofzia, recommended for treatment of open angle glaucoma. This formulation has several disadvantages and has the potential to form particulate matter during its shelf life due to interaction with the preservative system. The current marketed formulation also uses a patented primary packaging component to stabilize the formulation. Thus, an effort was made to select alternate surfactants for dissolving Travoprost in micellar solutions. Design of Experiments was used for screening a combination of four surfactants namely, Cremophor RH 40, Cremophor EL, Polysorbate 80 and Solutol HS 15 using Optimal Custom Mixture design. Particle size and polydispersity index (PDI) were measured as responses. A combination of two surfactants was chosen based on the lowest polydispersity index. Further optimization of surfactant concentrations was done using a Response Surface Optimal design. The results of particle size and PDI were evaluated statistically using regression analysis. All the experiments gave a particle size in the nano range of less than 20nm.

Keywords: Travoprost, Micellar solution, Surfactants, Design of experiments, particle size, Polydispersity Index.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)