EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

IDENTIFICATION OF POLYMER SYNERGY WITH HELP OF DOE

Simta Sharad Jadhav*, Milind Jagannath Bhitre and Kavita Vikram Inamdar

ABSTRACT

Ophthalmic solutions undergo rapid clearance from eye due to instant tear drainage, lower volume of cul-de-sac and lesser contact time with eye. All these drawbacks of ophthalmic solutions results in less efficacious product or requires repeated dosing. Repeated dosing of formulation could lead to lesser patient compliance and possible adverse effects. There are numerous approved polymeric ingredients available for ophthalmic use; however less information is available on their synergies. Hence there was a need to identify synergies among various polymeric ingredients with increased adhesiveness for sustained release ophthalmic formulations. Formulation adhesiveness is the function of viscosity being directly proportional; it plays a major role to sustain the drug release by increasing the contact time in eye with help of muco-adhesive forces or by polymer inter-penetrated network (IPN). Choice of selection of polymeric ingredients were based on their individual viscosities. Significant synergies were considered for those combinations which have higher viscosities compared to their individual viscosities at lower concentrations. The identified synergistic combination was also studied for stress study with the impact of pH, buffers and temperature during steam sterilization process.

Keywords: Ophthalmic, Polymer, Synergy, Viscosity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)