IDENTIFICATION OF POLYMER SYNERGY WITH HELP OF DOE

Simta Sharad Jadhav*, Milind Jagannath Bhitre and Kavita Vikram Inamdar

ABSTRACT

Ophthalmic solutions undergo rapid clearance from eye due to instant tear drainage, lower volume of cul-de-sac and lesser contact time with eye. All these drawbacks of ophthalmic solutions results in less efficacious product or requires repeated dosing. Repeated dosing of formulation could lead to lesser patient compliance and possible adverse effects. There are numerous approved polymeric ingredients available for ophthalmic use; however less information is available on their synergies. Hence there was a need to identify synergies among various polymeric ingredients with increased adhesiveness for sustained release ophthalmic formulations. Formulation adhesiveness is the function of viscosity being directly proportional; it plays a major role to sustain the drug release by increasing the contact time in eye with help of muco-adhesive forces or by polymer inter-penetrated network (IPN). Choice of selection of polymeric ingredients were based on their individual viscosities. Significant synergies were considered for those combinations which have higher viscosities compared to their individual viscosities at lower concentrations. The identified synergistic combination was also studied for stress study with the impact of pH, buffers and temperature during steam sterilization process.

Keywords: Ophthalmic, Polymer, Synergy, Viscosity.