EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

SPHERICAL CRYSTALS OF METRONIDAZOLE: TO IMPROVE SOLUBILITY, DISSOLUTION RATE AND MICROMERITIC PROPERTIES

Ethiraj T.*, Ganesan V., Revathi R., Arun V., Irsath M., Karthi A. and Loganathan T.

ABSTRACT

Spherical crystals of Metronidazole were prepared by Quasi Emulsion Solvent Diffusion method using a three solvent system comprising ethyl acetate as a good solvent, cyclohexane as a poor solvent and water as a bridging liquid. Hydroxy propyl methyl cellulose (HPMC) was used as hydrophilic polymer. The obtained spherical agglomerates were characterised by various parameters such as melting point, optical microscopy, particle size, angle of repose, crystal density, porosity, scanning electron microscopy, infra red spectroscopy, powder x-ray diffraction studies, solubility studies, in-vitro release studies. The prepared agglomerates showed marked increase in solubility and its dissolution behaviour than the pure one, and found improved micromeritics properties. It was revealed that the above spherical agglomerates exhibited considerable improvement in flowability, packability, wettability and compressibility.

Keywords: Metronidazole, Spherical agglomerates, Quasi emulsion solvent diffusion, Dissolution, Flowability, Packability.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)