EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

PROSPECTIVE STUDY OF EFFECT OF GLUCOCORTICOIDS IN THE TREATMENT OF VESTIBULAR NEURONITIS

*Dr. R. Siva MS (ENT) and Dr. M. Krishna Sundari

ABSTRACT

Objective: To study the efficacy of glucocorticoid treatment in acute vestibular neuronitis on recovery of vestibular function and the duration of hospital stay. Study Design: Prospective, comparison of consecutive case series with historic controls. Setting: Government Dharmapuri medical college hospital. Patients: Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 days after the onset of symptoms[n=30] and the other group of untreated historic controls[n=40]. Interventions: Oral Prednisolone at a dose of 50 mg/day for the first 5 days followed by tapering of the doses for the next 5 days, alternatively with intravenous Betamethasone 8 mg on the first 1-2 days if nauseated. Main Outcome Measures: Extend of unilateral vesibular paresis (%) in the caloric test at presentation and at 12months of follow up. Duration of hospital stay (days). Results: The initial vestibular paresis value was same for the treatment group and the control group. A lower value (22.8% versus 47.2%) and greater improvement was seen in the treatment group on follow up. About 70% of the treatment group had a normal caloric test result compared to only 34% of the of the control group. The mean hospital stay of the treatment group was significantly shorter than that of the control group (1.8 versus 3.0 d, p=0.001).

Keywords: Clinical medicine-Treatment outcome-vertigo-vestibular function tests.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia