SAFETY AND EFFICACY WITH GASTRIC TOLERABILITY OF THE FIXED DOSE COMBINATION OF ACECLOFENAC, PARACETAMOL AND RABEPRAZOLE IN THE TREATMENT OF ACUTE PAIN

Nandagopal Anitha* and Shaik Muddasir

ABSTRACT

Pain is defined as “An unpleasant sensory and emotional experience arising from actual or potential tissue damage or described in terms of such damage”. This definition recognizes that pain is a perception and not a sensation. The purpose of this study is to compare the safety and efficacy of our fixed dose combination with the reference for 6 month in 36 patient with rheumatoid arthritis. The combination of drugs Aceclofenac 100mg + Paracetamol 325mg + Rabeprazol 10 mg is a novel concept of anti-inflammatory properties with increase gastric tolerability. Pain was evaluated using Western Ontario and McMaster Universities Arthritis Index (WOMAC) & Visual Analog Scale (VAS). These scales are used to measure the pain index. The safety of the fixed dose combination in terms of pain after the treatment in test group was found to be 72% where as in reference it was about 55%. Hence it can be concluded that our fixed dose combination showed better therapeutic benefit than the reference drug.

Keywords: Pain, rheumatoid arthritis, Aceclofenac, Paracetamol, Rabeprazol, anti-inflammatory.