SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF PARACETAMOL AND CODEINE
Ahmed Mahdi Saeed* and Noor Qasim Ahmed
A novel, accurate, and simple UV – spectrophotometric method for simultaneous determination of paracetamol (PCM) and codeine (COD) in mixture of standard and tablets formulation was verification in this work without any separation method between the two drugs. The maximum absorbance of drugs in mixture was found to be at ( 243 nm and 278 nm) for PCM and COD respectively, in deionized water: acetonitrile mixture (90:10 v/v) as solvent. These wavelengths were selected for the analysis of drugs as mixture standard and formulated samples. The purposed method is linear in the concentration range of ( 0.3 – 30 μg/mL) for PCM and COD in the mixture respectively, with R2 values of (0.9993, 0.9995 ) for PCM and COD. Recovery means were found to be (99.04, 100.53 ) for PCM and COD respectively. The method was applied for the estimation of the active gradient of the drugs in different samples of formulated dosage. The accuracy of method was validated by mean percentage recovery which was found to be in the acceptable range.
Keywords: Novel, Simultaneous, Formulated, Recovery.
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