EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

STUDY OF BIOCHEMICAL MARKER TARC FOR HODGKIN LYMPHOMA IN HUMAN AND ITS RELATION WITH CLINICO–PATHOLOGICAL BEHAVIOR

Hossam Darwish*, Lamiaa Barakat and Rania Bondok

ABSTRACT

Back ground: Lymphomas can affect any organ in the body and present with a wide range of symptoms and is a curable disease in most patients. In the present study, TARC is the main parameter to prognosis of Hodgkin lymphoma, its positive Hodgkin Reed-Sternberg (HRS) cells has been found in Hodgkin patients. TARC serum levels are significantly high in classical Hodgkin Lymphoma (cHL) patients, so, identification of sensitive biomarker to improve the prognosis related Hodgkin lymphoma is needed. Aim of the work: The aim of the present study was to discuss the prognosis utility of serum TARC in patients for Hodgkin lymphoma during and post therapy the clinical advantage of this marker will be decreased or normal during or post therapy. TARC is a marker used for diagnosis and in follow up the patients for Hodgkin lymphoma. Results: Serum TARC was significantly in most patients for Hodgkin lymphoma. The receiver operating characteristic curve (ROC) curve showed the best cutoff values for TARC was 150 ng / l. Area under the curve of TARC was 0.84, to differentiate patients with complete response from those with partial response. The area under the ROC curve (AUC) was 0.826 with sensitivity 81.3% and specificity 74.4%. To differentiate patients with early stage from those with late stage, the area under the ROC curve was 0.840 with sensitivity 88.0% and specificity 75.0%, and to differentiate patients with B-symptoms from those with no B-symptoms, the area under the ROC curve was 0.860 with sensitivity 86.0% and specificity 75.0%. Conclusion: Results revealed that serum TARC may be used as potential prognostic marker for Hodgkin lymphoma patients.

Keywords: Hodgkin lymphoma patients, thymus and activation-related chemokine (TARC).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)