EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EVALUATION OF DICHLORVOS INHALATION ON THE LIVER HISTOLOGY AND SELECTED LIVER ENZYMES ACTIVITIES IN ADULT WISTAR RATS

*Idris Abdu Tela and Abdullahi Gudaji

ABSTRACT

Dichlorvos is one of the cheapest insecticides use to eradicate mosquitoes in Nigeria. It forms the active ingredient of the solution called Ota piapia or Madarar piapia. It binds irreversibly with acetylcholine receptors and inhibits its activity. It is metabolized in the liver and kidney. Oral ingestion of dichlorvos was commonest cause of toxicity reported however few literatures were reported on the effect of dichlorvos inhalation on the liver. The aim of this study was to evaluate the effects of dichlorvos inhalation on the liver histology and selected liver enzymes in Adult Wistar Rats. Twenty five apparently healthy Adult Wistar Rats were randomly selected and divided into five groups. Group one was used as control the rest were used as treatments for twenty eight days. The animals were sacrificed; their blood and liver tissues were collected for enzyme assay and routine histological technique respectively. Significant increase [P ˂ 0.05] in the values of the Albumin, Alkaline Phosphatase, Aspartate Aminotransferase and Alanine Aminotransferase as well as variable degrees of apoptosis and steatosis were observed in dose dependent manner in the treatment groups. Dichlorvos inhalation damaged histo-architechture and altered enzymes activities of the liver.

Keywords: Dichlorvos, inhalation, histology, liver enzymes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)