EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

THE PREGNANCY VARIABLE IN WOMEN WITH HETEROZYGOUS BETA THALASSAEMIA

Gülüzar Özbolat*, Nevin Y?lmaz, Yusuf Dö?ü? and Abdullah Tuli

ABSTRACT

Objectives: This study was designed to determine the RBC indices and HbF and HbA2 levels of before and during pregnancy periods of heterozygous -thalassemia individual. Methods: The study was designed retrospectively among the 60 heterozygous individuals with heterozygous -thalassemia. In this study before and during pregnancy periods hematological outcomes of individual have been systematically documented. Results: The RBC indices were in non-pregnant group; Mean (min-max): RBC 4.98 mil/mm3 (3.81-5.80), Hb 11.76 g/dL (9-14.20), Hct 35.39% (30,20- 41) and HbF % 0.7, (0.3-1.4) and HbA2 % 4.28 (2.7- 4.7) pregnant group; RBC 3.93 mil/mm3 (2,34-5.23), Hb 10.31 g/dL (7,70-12.30), Hct 31.83 % (22,90- 37,60) and HbF % 2.37 (0.4-4.9), HbA2 % 4.87 (2.8-4.9) . The 30 heterozygous individuals with β-thalassemia of the non-pregnant group consisting of RBC, Hb and Hct levels were higher than the values in pregnant group. The difference between the two groups was statistically significant (P <0.05). The pregnancy related changes in HbF and HbA2 levels values have been observed in 30 pregnancies in 60 women with heterozygous β-thalassemia individual. Statistically significant increases in pregnancy period were observed. HbA2 level is elevated in pregnant women. Conclusion: According to the results obtained in this study; pregnancy is a preanalytical variable on individuals with heterozygous -thalassemia individual for RBC, Hb, Hct, HbF and HbA2 levels. For this reason; the decreasing values of RBC, Hb and Hct depends to pregnancy may cause to interpret of heterozygous individuals as homozygous.

Keywords: ?-Thalassemia, RBC indices, pregnancy, preanalytical variable, HbA2.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)