EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

VALIDATION OF A NON-OFFICIAL ANALYSIS METHOD FOR A GRANULATED PRODUCT BASED ON GLUCOSAMINE AND CHONDROITIN

Lester Rojas-Quesada, German L. Madrigal-Redondo*, Rolando Vargas-Zuñiga and Santiago Rodríguez-Sibaja

ABSTRACT

Introduction: Glucosamine and chondroitin are structural constituents of the extracellular matrix of articular cartilage; they provide the cartilage with its mechanical and elastic properties for its ability to retain water. These are widely used today for the treatment of osteoarthritis worldwide and are classified as Symptomatic Slow Action Drugs for Osteoarthritis (SYSADOA). Objective: To develop and validate a non-official method of analysis for the assay of a product based on glucosamine and chondroitin in the form of granules. Method: A High-resolution liquid chromatography (HPLC) method was developed and validated, emphasizing that there is currently no other official HPLC method for the analysis of these active ingredients. The procedure used a C18 chromatographic column at a mobile phase flow of 1 mL / min and using an injection volume of 10 μL. The active ingredients of the analyzed product are in the form of sodium hydrochloride for glucosamine and sodium sulfate for chondroitin. Results: The results obtained for the analysis of each validation performance parameter met the established acceptance criteria. Conclusions: By accepting each of the performance parameters for the developed method, it can be concluded that it is duly validated and can be reliably used.

Keywords: Glucosamine, chondroitin, osteoarthritis, high performance liquid chromatography, analysis method, validation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)