EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EFFECT OF THE MONGOLIAN MEDICINE "GARLICLAXATIVE" IMPACT THERAPY ON ALCOHOLIC PERIPHERAL NERVE

Tseebaatar Ankhtsetseg and Tao Li*

ABSTRACT

Objective: Using the Mongolian medicine "Garlic laxative," impact therapy on alcoholic peripheral neuropathy treatment mechanism for the Mongolian medicine application in the study of neurological diseases lay the foundation. Methods: Randomly selected 50 adult male rats as experimental animals and divided into some groups such as control group (Con group), model group (Model group), Methycobalgroup (Mecbl group), “Garlic change laxative” side group (Garlic group) and thecombinedmethycobal "Garlic laxative" group (Mecbl + Garlic group), 10 models in each group. Results: Electrophysiological test results showed that the conduction velocity of the sciatic nerve in rats was significantly slowed down after model establishment (P <0.05), and the nerve conduction velocity in model group was the slowest after the model was established. The nerve conduction velocity in Mecbl + Garlic group was the fastest Model group, Mecbl group and Garlic group (P <0.05), slightly higher than Con group, but no significant difference (P> 0.05). ELISA results showed that after model establishment, the expression of nerve growth factor (P <0.05). After the administration, the concentration of nerve growth factor in the model group was the lowest. Moreover, the nerve growth factor in Mecbl + Garlic group was the highest, significantly higher than that in Model group, Mecbl group and Garlic group (P <0.05) Mecbl + Garlic group compared with Con group, slightly higher but no significant difference (P> 0.05). Conclusions: The rat models of alcoholic axial neuropathy were established and treated for eight weeks respectively. The indexes of 5 rats were evaluated. The nerve conduction velocity was detected by the electrophysiological method and the enzyme-linked immune-sorbent assay Concentration of Nerve Growth Factor in Rats. Thus prove the Mongolian medicine "Garlic laxative" has a significant effect on the regulation of sciatic nerve conduction and the related factors of nerve factors in alcoholic peripheral neuropathy rats, which may have positive significance for the treatment, which deserves attention.

Keywords: Alcoholic peripheral neuropathy; rat experiment; Mongolian medicine; garlic albumen laxative; impact therapy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)