EFFECT OF IL6 C-174G POLYMORPHISM ON RESPONSE TO STEROID THERAPY IN EGYPTIAN CHILDREN WITH NEPHROTIC SYNDROME
Mona Abo Bakr El-Hussiny*, Faten Zahran Mohamed, Lamiaa Abd El-Lateaf Ali Barakat, Mohamed Magdy Zedan and Mohamed Adel Abd El-Motelb El-Eshmawy
Nephrotic syndrome (NS) is a common glomerular disorder in childhood. Interleukin-6 (IL-6) is a multifunctional cytokine its polymorphism is considered as an aggravating factor in the development and progression of renal disease. The aim of the current work was to investigate the serum level of IL6 and the association between IL 6 G-174C polymorphism and the response to steroid therapy in nephrotic syndrome. This study was conducted on 250 subjects classified into the following groups: Group I: included 100 healthy children, Group II: included 50 steroid sensitive nephrotic syndrome, Group III: included 100 steroid resistant nephrotic syndrome patients. Serum IL6 was estimated by ELISA technique. IL6 C-174G gene polymorphism was evaluated by PCR/RFLP method.
Keywords: Nephrotic Syndrome, IL6, gene polymorphism, Egyptian.
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