EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EFFECT OF IL6 C-174G POLYMORPHISM ON RESPONSE TO STEROID THERAPY IN EGYPTIAN CHILDREN WITH NEPHROTIC SYNDROME

Mona Abo Bakr El-Hussiny*, Faten Zahran Mohamed, Lamiaa Abd El-Lateaf Ali Barakat, Mohamed Magdy Zedan and Mohamed Adel Abd El-Motelb El-Eshmawy

ABSTRACT

Nephrotic syndrome (NS) is a common glomerular disorder in childhood. Interleukin-6 (IL-6) is a multifunctional cytokine its polymorphism is considered as an aggravating factor in the development and progression of renal disease. The aim of the current work was to investigate the serum level of IL6 and the association between IL 6 G-174C polymorphism and the response to steroid therapy in nephrotic syndrome. This study was conducted on 250 subjects classified into the following groups: Group I: included 100 healthy children, Group II: included 50 steroid sensitive nephrotic syndrome, Group III: included 100 steroid resistant nephrotic syndrome patients. Serum IL6 was estimated by ELISA technique. IL6 C-174G gene polymorphism was evaluated by PCR/RFLP method.

Keywords: Nephrotic Syndrome, IL6, gene polymorphism, Egyptian.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)