EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

IN-VITRO ANTI-INFLAMMATORY, ANTI-OXIDANT AND IN-VIVO ANALGESIC, ANTI-DIARRHEAL ACTIVITIES OF FRACTIONAL LEAF EXTRACTS OF HIBISCUS SURATTENSIS

Sayema Sultana, Abdullah Al Faruq, Nahid-Al-Rashid, Dr. Talat Nasim and Md. Qamrul Ahsan*

ABSTRACT

Objective: To determine the effect of fractional extracts (ethanol, chloroform and n-hexane) of Hibiscus surattensis in treating inflammation, oxidant, pain and diarrhea using in vitro and in vivo experimental models. Methods: The activities of different fractional plant extracts were tested for protein denaturation of egg albumin. Additionally, inhibition of DPPH free radical, acetic acid-induced writhing and castor oil-induced diarrheal models were applied for evaluation of anti-inflammatory, anti-oxidant, analgesic and anti-diarrheal activities respectively. Results: All tested extracts demonstrated a significant (*P< 0.05, **P< 0.005) mild to moderate activity of inhibition of protein denaturation compared with the positive control group of acetyl salicylic acid. Extracts also showed significant (*P< 0.05) moderate inhibition of DPPH free radical scavenging activity compared with the standard drug ascorbic acid at the similar doses. In analgesic test, these extracts significantly (*P<0.05) reduced the number of writhing and increased the mean latent period of defecation in castor oil-induced diarrheal model mice at the dose of 500 mg/kg body weight. Conclusions: These results suggest that the crude leaf extracts possesses significant anti-inflammatory (mild to moderate), anti-oxidant (moderate), analgesic and anti-diarrheal activities. These observations offer the opportunity for the identification of more active chemical entities, which may support the clinical and experimental uses of this plant.

Keywords: Anti-inflammatory; anti-oxidant; analgesic; anti-diarrheal and Hibiscus surattensis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)