EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANALYSIS OF MEROZOITE SURFACE PROTEIN-3? IN PLASMODIUM VIVAX ISOLATES COLLECTED FROM SOUTHWESTERN COASTAL REGION OF INDIA

Shiny Joy, Dr. Susanta K. Ghosh, Dr. Rajeshwara N. Achur, Dr. Sucheta Kumari, Prof. D. Channe Gowda, Prof. Namita Surolia*

ABSTRACT

Background: Malaria is one of the major infectious diseases and is a global health threat. Malarial parasites exhibit high genetic diversity, Which is one of the reasons hampering the vaccine development. Analysis of genetic variations in known vaccine candidates is crucial for developing an effective vaccine. The current study was aimed at analysing one of the members of the merozoite surface family of proteins, MSP- 3β, of Plasmodium vivax (Pv) in parasite samples collected from patients from southwestern coastal region of India, where prevalence of P. vivax predominates compared to P. falciparum. Method: A total of 25 field isolates were analysed in the study. Allelic diversity at the Plasmodium vivax merozoite surface protein-3β locus was investigated using a combined polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) procedure. Results: PCR products of PvMSP-3β revealed three allelic variants. Digestion with Pst 1 restriction enzyme yielded suballelic variants. A total of five different alleles were observed in the current study. Conclusion: Even though the samples were limited, PvMSP-3β was found to be significantly variant in the isolates from this area. Further studies using substantially more samples would provide definitive information about the extent of polymorphisms in P. vivax isolates in this area.

Keywords: Malaria, merozoite surface protein 3 beta, Plasmodium vivax, Mangalore.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)