EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ISOLATION OF OCTADECANEDIOIC ACID FROM CASSIA FISTULA LINN AND ITS BIOLOGICAL EVALUATION

Brinda Bolar and *Gangadhar A. Meshram

ABSTRACT

Cassia fistula L., a semi wild Indian Labernum also known as the golden shower tree is an ornamental tree with beautiful bunches of yellow flower. It is highly reputed for its laxative and purgative properties. The extracts of cassia fistula are widely used as traditional antidiabetic medicines. One of the theraupatic approach for preventing diabetes mellitus-2 is to retard the glucose absorption in the blood via inhibition of glucosidase viz glucoamylase and α-amylase. In the present study Octadecanedioic acid was isolated from the bark of Cassia fistula. The structure was elucidated on the basis of MS, NMR and IR. Octadecanedioic acid exhibited potent inhibitory activity against glucoamylase and α-amylase with IC50 value 56μg/mL and 48μg/mL respectively. The antioxidant activity was evaluated by DPPH method. The results indicated that Octadecanedioic acid possess considerable antioxidant activity. The highest radical activity was detected at 81μg/mL. As a result Octadecanedioic acid was isolated from Cassia fistula can be used for antioxidant therapy during management of Diabetes Mellitus Type -2.

Keywords: Cassia fistula, Octadecanedioic acid, glucoamylase, ?-amylase, antioxidant activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)