SYNTHESIS AND BIOACTIVITY EVALUATION OF NEW BISSULFONAMIDES AND BISCARBAMATE DERIVATIVES OF 1, 5-DIAMINONAPHTHALENE
Umapriya Kollu, Nagalakshmamma Vadabingi, Venkatramaiah Chintha, Sreedhar N. Y. Naga Raju Chamarthi* and Rajendra Wudayagiri
Synthesis of a new series of N,Nâ€™-(Naphthalene-1,5-diyl)bis substituted sulfonamides 3(a-e) and N,Nâ€™- (Naphthalene-1,5-diyl)bis substituted carbamates 5(a-e) were synthesized from 1,5-diamino naphthalene (1) using various pharmacologically active sulfonyl chlorides (2) and carbonyl chlorides (4) in the presence of mild base. The chemical structures were characterized by IR, 1H and 13C NMR, mass and elemental analysis. The biological assay revealed that the compounds 3d, 5b are exhibited high inhibition activity against anti bacterial and antifungal strains.
Keywords: 1,5-diaminonaphthalene, sulfonamides, carbamates, antibacterial activity, antifungal activity.
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