SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF NEW INDOLOQUINOLINE – BIOTIN HYBRIDS
Elkhabiry Shaban*, Samah El-Ghlban, Marwa Samy, Ahmed Abdel Aleem El-Gokha and Ibrahim El-Tantawy El Sayed*
A series of indoloquinoline- biotin hybrids conjugates 7a-f were designed and synthesized in good yields to
improve and develop higher potency and selective anti-tumor agents. Their antiproliferative evaluation activities
against HePG2, HCT-116 and MCF-7 cell lines in vitro were tested using colorimetric MTT assay. These
neocryptolepines (2-substituted-5-methyl-indolo[2,3-b]quinolones) were synthesized via nucleophilic aromatic
substitution (SNAr) of the Cl leaving group of 11-chloroneocryptolepines with diamines which further hybrids by
reacting the 11-(aminoalkylamino) derivatives with biotin. The result of the present work indicated also that 7e, 7f
were good potent compared with doxorubicin and ultimately would be appreciated as potential anticancer agents.
Keywords: Chloroneocryptolepine, Biotin, aminoalkylamino-substituted, antiproliferative activity, doxorubicin.
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