EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EFFECT OF BETAMETHASONE ADMINISTRATION ON SKELETAL MUSCLES OF PREGNANT RATS AND THE AMELIORATIVE ROLE OF CURCUMIN

Gamal M. Badawy*, Hend T. El- Borm, Saber A. Sakr

ABSTRACT

Using the skeletal muscle as a target organ, the present study involved two integrated aspects. The first aspect has dealt with investigating the possible toxic side effects of maternal exposure to one of the glucocorticoids, namely, betamethasone for ten days i.e. from the 6th to the 15th day of gestation in female Wister rats. However, the second aspect examined the possible ameliorative role of curcumin against the toxicity induced by betamethasone administration. Three integrated approaches i.e. histological, histo-morphometric, and molecular were utilized. The drug group exhibited evident histological changes compared with the control group in the form of wide splitting of the skeletal muscle fibers in association with fibrillolysis and nuclear internalization. Furthermore, muscle fibers showed irregular variation in size with rounding of some of them. At the molecular level, SDS-PAGE for protein in the muscles exhibited a marked lose in most protein bands as compared with the control group. Administration of curcumin after betamethasone caused an evident amelioration at the three utilized approaches.

Keywords: Betamethasone; Skeletal muscle; Curcumin; Pregnancy; Histology, Histo-morphometric; Molecular; toxicity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)