EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

COMPARISON BETWEEN INDUCTION CHEMOTHERAPY FALLOWED BY CONCURRENT CHEMOTHERAPY VERSUS CONCURRENT CHEMOTHERAPY ALONE IN HYPOPHARNGEAL CARCINOMA-A PILOT STUDY

Bhaskar Viswanathan, Dr. Deepak and *Swathi Reddy

ABSTRACT

Background: The incidence of distant metastasis is quite high in patients of Hypopharyngeal cancers compared to concurrent chemoradition alone. Aims and objectives: To assess and compare 1) The loco-regional response and patterns of failure in carcinoma hypopharynx patients treated with induction chemotherapy followed by chemoradiation versus chemoradiation alone. 2) The toxicity profile in patients treated in 2 arms. Materials and Methods: 40 patients,(20 prospective for Arm A, 20 retrospective for Arm B presenting with T1N+, T2/T3 any N, M0 stages of Carcinoma Hypopharynx were enrolled. In Arm A, patients received Induction Chemotherapy (2 cycles of 3 weekly Inj.Paclitaxel 175 mg/m2 & Inj.Cisplatin 70mg/m2) followed by concurrent chemoradiation (2cycles of 3 weekly Inj.Cisplatin 70mg/m2. In Arm B, patients received Concurrent Chemoradiation alone (2cycles of 3 weekly Inj.Cisplatin 70mg/m2 .The radiation done was same in both arms at 7000cGy in 35 fractions at 2Gy/fraction. Results: In Arm A, showed more responses compared to Arm B. At 6 months, the complete response rate for Arm A was 88.9% compared to 66.7% in Arm B, though the difference was not statistically significant. None of the patients in Arm A developed progressive disease as opposed to 2 (10%) patients in Arm B. Toxicity profile of mucositis, haematological and dysphagia in both Arms were comparable. Interpretation & Conclusion: Sequential therapy (ICT+CTRT) was well tolerated and showed favorable improvement in tumour response rates and reduced treatment failure compared to patients treated with CTRT alone. Thereby sequential therapy offers a safe and effective means of management in T1N+, T2/T3 any N, M0 stages of Carcinoma Hypopharynx patients.

Keywords: Hypopharynx cancer; Radiotherapy; Sequential therapy; Induction Chemotherapy; Chemoradiation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)