EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

APPLICATION OF HPTLC FOR SIMULTANEOUS ESTIMATION OF ZALTOPROFEN AND PARACTAMOL IN COMBINED DOSAGE FORM.

N-K_Zahira* and P-N_Presannakumaran

ABSTRACT

A simple, sensitive HPTLC method has been developed for the estimation of Zaltoprofen and Paracetamol in combined dosage form. The stationary phase was pre-coated plates of silica gel G 60 F254 and the mobile phase used was Toluene: Isopropyl alcohol in the ratio 5:2. The Rf values were found to be 0.59 for Paracetamol and 0.78 for Zaltoprofen respectively. The plate was scanned and quantified at 254 nm. The calibration curve of Paracetamol and Zaltoprofen were prepared and it was found to be linear in the range of 200- 500 ng/2μl and 100-400 ng/2μl respectively. The correlation coefficient was found to be 0.9913 (Area wise) and 0.9932 (Height wise) for Paracetamol and 0.9907 (Height wise) and 0.9902 (Area wise) for Zaltoprofen. The percentages of label claim for Paracetamol were found to be 99.9654% (Height wise) and 100.066% (Area wise). Percentages of label claim for Zaltoprofen were found to be 100.0145% (Area wise) and 100.0644% (Height wise). The suggested methods were validated in compliance with the ICH guidelines and were successfully applied for determination of ZLT and PAR in their laboratory prepared mixture and commercial Tablet. This is a simple manipulation with maximum reproducibility and robustness, which can be used for the analysis of binary mixture with overlapped spectra for routine QC testing.

Keywords: Chromatography, Binary mixture, Paracetamol, Zaltoprofen.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)