EVALUATION OF WOUND HEALING ACTIVITY OF ABELMOSCHUS ESCULENTUS (LINN) IN ALBINO WISTAR RATS
Mohd Baleeghuddin Farooqui*, Dr. Shaik Mohammed Khasim, Mohd Rafiq, Ashfaq Ali Khan
ABSTRACT
Synthetic drugs which may suppress or relieve some diseases faster which are usually having harmful side effects therefore attention around worldwide has been shifting towards finding new herbal chemicals for the development of new drugs which are nontoxic. From the earliest times, man has started soughing and understanding the natural forces and risk factors affecting the patterns of illness and death in society. Wound was probably the first medical problem faced by the human race. A wound is the breakage of normal alignment of body cells with or without destroying them, which may impair or stop their function. The symptoms of wound or injury include swelling, stiffness, tenderness, discoloration skin tightness, itching and scar formation. Normal wound healing takes about 3 weeks, but some wounds can take months or even years to heal. Therefore it is necessary to take care for wound healing in initial state using safe medications. In the present study, an attempt has been made using aqueous extract of herbal based plant known as Abelmoschus esculentus (200mg/kg/day) in Wister albino rat against excision and incision wound model following standard procedures in the form of ointment base. In excision model, aqueous extract treated animals exhibit 19.37±0.15% reduction in wound area when compared to control which was 29.51±0.69% and whereas standard exhibit 17.73±0.26%. The extract treated wounds are found to epithelize faster as compared to control. In incision wound model significant (p<0.001) increase in breaking strength 305.18±2.36**was observed where as in control group it was 116.91±2.73 and in standard it was 325.45±4.77**The Framycetin sulphate ointment (FSC) 1% w/w was used as standard. The results of the present study clearly suggested that Abelmoschus esculentus posses potent wound healing activity, which could be a good choice of remedy for wound healing and it can be strongly recommend in different wound healing models like burn wound, dead space wound, injury by X-ray radiation and ultraviolet light etc.
Keywords: Abelmoschus esculentus, Wound healing, Excision wound, Incision wound, Framycetin sulphate ointment.
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