EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EFFECT OF SHRIMP SHELL EXTRACT NANOPARTICLES ON ORAL SQUAMOUS CELL CARCINOMA CELL LINE: IN VITRO STUDY

Dina Sabry Abd-El-Fattah, Wael Sabry Mohammed and *Marwa Mohammed Ellithy

ABSTRACT

To develop a shrimp shell extract based nanoparticles formulation and assess its effect on the viability and carcinogenic potential of human oral squamous cell carcinoma cell line Hep-2 in vitro. Nanoparticles of chitosan were prepared. Characterization was based on particle size, zeta potential, and morphology. Various concentrations of chitosan nanoparticles (0.3- 0.6- 1- 1.5 mg/ml) were used intreating cells for 48 hours then cell viability was assessed to calculate the IC50. VEGF and TNF-α were measured in plates of cells treated with Chitosan nanoparticles in its IC50 concentration. MTT assay results showed that chitosan nanoparticles exhibited concentration dependant cytotoxicity on the Hep-2 cell line. Chitosan nanoparticles are cytotoxic to Hep-2 cell line in-vitro and decreases the angiogenic marker VEGF and TNF-α in a dose dependant way. So, shrimp shell extract nanoparticles could be used as a natural agent in oral cancer therapy.

Keywords: Shrimp shell, Chitosan, nanoparticles; oral cancer; angiogenesis, TNF-?.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)