EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ENDOCAN: A RELIABLE BIOMARKER FOR RENAL IMPAIRMENT IN PSORIASIS VULGARIS PATIENTS

Azza G. A. Farag, M.D.*, Elsayed I. Elshayeb, Mona S. Habib, M.D., Reda A. Ibrahem, M.D., Masroor Qutubuddin and Reda Z. Mahfouz, M.D.

ABSTRACT

Background: Endocan may play a possible indicator for vascular endothelial related pathologies. Severe psoriasis is a risk factor for chronic kidney disease. Endocan may predict renal impairment in psoriatic patients. Aim(s): To assess risk of renal impairment in patients having psoriasis and to investigate the role of serum endocan in renal impairment in these patients. Methods: We have estimated glomerular filtration rate (eGFR) and examined serum endocan level in normotensive non-diabetic psoriasis patients (n=70) controlled to age- and gender- matched volunteers (n=60). Psoriasis area severity index (PASI) score was used to assess psoriasis severity. Results: eGFR was significantly low in psoriasis patients than controls (p = 0.02), and in sever than moderate psoriasis (p = 0.02). Endocan serum level showed a significant elevation among psoriatic cases than controls (p < 0.001), and was correlated positively with psoriasis severity (r=0.83, p < 0.001), and negatively with eGFR (r= - 0.43, P < 0.001). Severe psoriasis patients had odds ratio (OR) of 2.5 getting renal impairment compared to moderate psoriasis. The best cutoff of endocan was 507.23 pg/mL for detection of early kidney impairment in psoriasis patients (sensitivity =87.5%, specificity=82.3%, accuracy=82.9%) with area under the curve of 0.79. Psoriasis patients with high serum endocan had 2.3 OR of getting renal impairment. Conclusion: Serum endocan is associated with psoriasis severity and may be a sensitive and accurate predictive biomarker for early detection of renal impairment in psoriasis patients. Renal impairment has OR of 2.5 in severe psoriasis and of 2.3 in psoriasis patients with high endocan.

Keywords: psoriasis, renal impairment, eGFR, endocan, biomarker.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 August 2018 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR AUGUST ISSUE PUBLISHED

    AUGUST 2018 Issue has been successfully launched on 1 August 2018

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)