EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

THE ROLE OF ALOE VERA ON HAEMATOLOGICAL PARAMETERS FOLLOWING PHENYLHYDRAZINE (PHZ)-INDUCED ANAEMIA IN WISTAR RATS

Elemi J. Ani*, Akaninyene U. Ime, Augustine L. Udefa and Udemeobong E. Okon

ABSTRACT

The effect of Aloe vera on some haematological indices in phenylhydrazine-induced anaemic rats was studied. Fifteen female wistar rats weighing 180-220grams were used for this study. They were randomly divided into three groups (n=5) thus: Group A: Control; Group B: Induced with anaemia using PHZ at a dose of 0.5ml/100g body weight on days 1, 3, 5 and 7. Group C received the same treatment as B and additionally treated daily with aloe vera gel administered orally at a dose of 0.6ml/kg b.w., one week after induction of anaemia. All groups received normal rat chow and water ad libitum. The feeding and treatment lasted for 28days and thereafter, the rats were subjected to sacrifice following standard methods and blood collected via cardiac puncture into EDTA sample bottles for analysis. Aloe vera treated group showed a significant increase in the mean food and water intake compared to B. A marked reduction in body weight was seen in group C compared to control while aloe vera treated group showed a significant increase in body weight compared to group B. A marked decrease in Hb, RBC count was seen in group B compared to control. Conversely, Aloe vera treated group had a significant increase in Hb and RBC count when compared to group B. Total white cell count was significantly increased in group B compared to control and Aloe vera treated groups. This trend was also observed for platelet count. From these results, Aloe vera treatment showed potent ameliorative effect following anaemia.

Keywords: Anaemia; Phenylhydrazine; Aloe vera; Red blood cell; white blood cell; platelet.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)