EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

MORPHOLOGICAL ANALYSIS OFCHITOSAN-ACACIA GUM NANOPARTICLES LOADED AND UNLOADED WITH CISPLATIN

Kunle Joseph Akinluwade*, Grace Modupe Oyatogun, Gbenga Alebiowu and Abimbola Patricia Popoola

ABSTRACT

In this study, chitosan-based and cisplatin-laden nanoparticles formed from cowry shells and acacia gum were synthesized with an investigation of the morphology and dimension of the nanoparticles. Chitosan and gum arabic were extracted from cowry shells and Acacia trees respectively to prepare nanoparticles using standard chemical methods. Observation with a Jeol JSM 7600F Field Emission Gun Ultra-High Resolution Scanning Electron Microscope confirmed the formation of particles composed of distinct spheres, ovals, and short cylinders. The study further investigated the morphology of the nanoparticles before and after loading with cisplatin, a multipurpose anti-cancer drug. Quantitative morphological description of nanoparticles was done using shape factors such as aspect ratio, roundness, irregularity and equivalent circle diameter (ECD), which were obtained from Media cybernetics software analysis while qualitative description was done on the basis of visual observation of acquired SEM photomicrographs. Results showed that the respective values of aspect ratio (0.67 and 0.68), roundness (0.91 and 0.95), irregularity (2.69 and 2.80) and ECD (0.67 and 0.80) obtained for cisplatin-unloaded and cisplatin-loaded nanoparticles are strikingly comparable providing evidence that drug encapsulation did not impair the morphological attributes of the nanoparticles significantly. The developed nanomaterials are thus considered suitable as nanocarriers for targeted drug delivery applications.

Keywords: Cowry shells, cisplatin, Acacia gum, nanoparticles, shape factors, Media cybernetics.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)