EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

THE CARDIOPROTECTIVE EFFECT OF ARGEMONE MEXICANA ON ISOPROTERENOL INDUCED CARDIAC TOXICITY IN RATS

Shirish S. Patil*, Dr. N. S. Naikwade and T. S. Shikalgar

ABSTRACT

Cardiovascular diseases comprise the most prevalent serious disorders in the developed nations. Cardiotoxicity occurs during therapy with several drugs and may be the dose limiting factor in the treatment. In similar to, Isoprenalin (a synthetic catecholamine and beta adrenergic receptor) has been found to cause severe cardiac damage. Clinical and experimental investigations suggested that increased oxidative stress associated with an impaired antioxidant defence status initiates a cascade of reactions responsible for Drugs induced cardio toxicity. The interest to undertake this investigation is due to Argemone mexicana could be a potential source of natural antioxidant, that could have greater importance as medicinal agent in blocking or slowing oxidative stress related degenerative diseases. Argemone mexicana have been reported for in vitro oxidant activity. The present study aimed to evaluate cardioprotective potential screened in Isoproterenol induced cardiac stress in which Ethanolic Extract of Argemone Mexicana Leaves (EAML 200 mg/kg,400mg/kg) were administered & Isoproterenol (85mg/kg s.c.) administered groups respectively. The present study concludes that restoration of Hemodynamic Parameters(BP,ECG),Biochemical Parameters-cardiac markers(CK-MB,LDH,SGOT), antioxidant markers(MDA,CAT,SOD,GTH)) Histopahological indications.

Keywords: Isoproterenol, Antioxidant, ECG, blood pressure, cardiotoxicity..


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)