EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

COMPARISON OF ANALGESIC EFFECTS OF INTRAVENOUS NALBUPHINE AND PENTAZOCINE IN PATIENTS POSTED SURGICAL PROCEDURE: A PROSPECTIVE RANDOMIZED DOUBLE BLIND STUDY

Dr. Uma Shankar Gupta, Mayur Gupta* and Palak Chavda

ABSTRACT

Background and objectives: Postoperative pain is acute pain and can affect nearly every organ function and may adversely influence postoperative morbidity and mortality. Pharmacological management with intravenous opioids is a common, effective and a well known method used to treat this pain. Primary objective was to compare effects of intravenous nalbuphine and intravenous pentazocine in terms of duration of analgesia and secondary objective was to study side effect profile. Methods: 60 American Society of Anaesthesiologists (ASA) physical status I and II patients undergoing short duration surgery under general anaesthesia were randomly allocated in two groups of 30 each to receive either nalbuphine(group A) or pentazocine (group B) intravenously. Patients were monitored for any side effects, postoperative duration of analgesia and need for rescue analgesia. Two sample t-tests was used to investigate and model the impact of various parameters like duration of analgesia and side effect profile. Results: Duration of analgesia in group A (7.43±1.63hours) was significantly prolonged as compared to group B (4.73±1.62hours). The difference was statistically significant (p <0.05). Sedation was not significant in group A as compared to group B. Conclusion: Nalbuphine, a synthetic opioid agonist- antagonist provides good postoperative analgesia in minor general surgical patients as compared to fentanyl and pentazocine, hence useful in day care surgeries.

Keywords: Nalbuphine, pentazocine, postoperative analgesia.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)