EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

STUDY OF SOCIO CLINICAL, BIOCHEMICAL AND ECG ASPECTS OF YELLOW OLEANDER POISONING

Dr. T. Grashia,MD and Dr. J. Bharath*

ABSTRACT

Introduction: The yellow oleander, an evergreen shrub or a small tree of Apocyananceae family is widely distributed over the tropics. Yellow oleander (Thevetia peruviana), is one of the most poisonous plants which contains numerous toxins .The toxic effects resemble that of digitalis toxicity. The use of seeds or fruits of yellow oleander as a method of self-harm is common in South India. Severely poisoned patients may die in DC shock resistant ventricular fibrillation. It can lead to severe Hyperkalaemia which is a marker of a poor outcome in cardiac glycoside poisoning, which may worsen further toxicity and lead to serious Arrhythmias. Aim & Objectives: To find out the incidence of yellow oleander poisoning and to analyze the socio-clinical aspects. Also to correlate the clinical and biochemical data with electrocardiographic changes. Materials and methods: All patients admitted with consumption yellow oleander poison was studied. The study was carried out over a one year from June 2008 – May 2009. Clinical parameters, CBC, Serum Urea, Creatinine, Serum Na+, Serum K+ and ECG were done to analysis the changes on hourly basis. Results: 160 patients with yellow oleander poisoning were included in the study of which 54 were males and 106 were females. Most patients had consumed oleander in a suicidal intention. 1.73% of patients had underlying psychiatric illness. Case fatality rate was 7.5%. The most common electrocardiographic abnormality was sinus bradycardia. Life threatening arrhythmias were seen in 6.8%. There was significant correlation between outcome and serum potassium levels, bicarbonate levels, and delay in seeking medical attention, and number of symptoms at presentation. There was no correlation between number of seeds consumed and outcome or cardiotoxicity. Oleander seed is still used as a suicidal agent. Oleander plant is easily available as an ornamental plant in urban, semi-urban and rural areas. Highly symptomatic patients and those who has delay in seeking medical attention showed more cardio toxicity. Hence earlier treatment and symptomatic management will help in reducing complications and mortality.

Keywords: Oleander seed, Hyperkalaemia, ECG abnormalities, Cardiac glycoside poisoning.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)