CAN MEAN PLATELET VOLUME/PLATELET COUNT RAT?O BE USED TO PRED?CT THE MORTAL?TY ?N ACUTE ?SCHEM?C STROKE PAT?ENTS?
Asli Bolayir* and Hasan Ata Bolayir
Objective: It is revealed that, increased mean platelet volume/platelet count ratio (MPV/PC), obtained by dividing mean platelet volume (MPV), which indicates platelet function and activity, by platelet count, is associated with the increase of the thromboembolic disease risk. Our aim was to determine the effects of MPV and MPV / PC on the development of acute ischemic stroke (AIS) and 60- day mortality. Materials and Methods: Our study retrospectively included 512 patients with AIS between January 2010 and 2016, along with 408 age- and sex-matched controls. During their 60 day-hospitalization, 87 of these 512 patients died. Blood samples were taken to measure MPV and MPV/PC ratio within 24 hours. Patients and controls were compared in terms of MPV and MPV/PC values; these were also compared between non-surviving and surviving patients. Results: Patients had significantly higher MPV and MPV/PC values than controls; these results were similar between non-surviving and surviving patients. The univariate and multivariate logistic regression analyses indicated that MPV and MPV/PC were independent predictors of 60- day mortality in AIS. ROC analysis showed that cut-off values of 9.65 for MPV (AUC: 0.68, 95% CI: 0.54- 0.78, sensitivity: 54.1%, specificity:65%) and 0.047 for MPV/PC may be used to determine 60-day mortality due to AIS (AUC: 0.73, 95% CI: 0.65- 0.82, sensitivity: 71.1%, specificity: 68.3%). Conclusion: It could be suggested that MPV and MPV/PC values are increased in AIS patients, and that the elevations of MPV and especially MPV /PC values can be used to predict 60-day mortality in AIS patients.
Keywords: Mean platelet volume, platelet count, mean platelet volume/platelet count, mortality, acute ischemic stroke.
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