EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

GENOTYPIC CHARACTERIZATION OF ANTIBIOTICS RESISTANCE INTEGRONS IN EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING STRAINS OF E. COLI AND PROTEUS SPP. IN OUAGADOUGOU, BURKINA FASO

Dissinviel Stéphane Kpoda*, Innocent Kouamé Kouadio, Nathalie Guessennd, Aboubakar Sidiki Ouattara, Lassana Sangaré and Alfred S. Traoré

ABSTRACT

Introduction: During the 1980s, genetic elements that could acquire or lose genes for antibiotic resistance were identified and referred to as integrons. The aim of this study was to genotypically characterize integron in extended-spectrum beta-lactamase producing E. coli and Proteus spp. strains. Materials and methods: 125 Extended Spectrum Beta Lactamases producing strains isolated from various biological products in 3 hospitals in Ouagadougou were used for this study. Isolates were subjected to antibiotic susceptibility test using the disc diffusion method: Class 1, 2 and 3 integrons investigation was performed by conventional Polymerase Chain Reaction. Results: 59.2% (74/125) strains including 61.5% (72/117) E. coli and 25% (2/8) Proteus spp. ESBL producers carried class 1 integrons. No isolates carried class 2 and / or 3 integrons. Strains carrying the resistance integrons showed 97.6% resistance to amoxicillin, 97.6% to cefotaxime, 98.4% to ceftriaxone, and 93.6% to cefepime, compared to those without integrons. Conclusion: This study revealed 59.2% of ESBLs strains which carried class 1 integrons. The link between resistance integrons and high levels of antibiotic resistance found in these strains poses a risk to public health and hence the need for increased surveillance and control of the indiscriminate use of antibiotics.

Keywords: E. Coli, Proteus spp., Integrons of Antibiotic Resistance, Ouagadougou.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)