ANTITUMOUR ACTIVITY OF QUERCETIN-3-O- ? -GLUCOSIDE ISOLATED FROM CANSJERA RHEEDII (OPILEACEA) AGAINST DALTONâ€™S ASCITIC LYMPHOMA
G. Revathi, M. Arthy, I. Stephen, P. Pradheepa, Pedapati Renuka Swathi, V. M. Mounnissamy*
The antitumour activity of Quercetin-3-O-Î²-Glucoside (5, 7, 3â€™, 4â€™-Tetrahydroxy-3-O-Î²-D-Glucopyranosyl flavone) isolated from aerial parts of Cansjera rheedii J.Gmelin (Opiliaceae) has been evaluated against Daltonâ€™s ascitic lymphoma (DAL) in swiss albino mice. A significant enhancement of mean survival times of Quercetin-3-O-Î²-Glucoside treated tumour bearing mice was found with respect to control group. Quercetin-3-O-Î²-Glucoside treatment was found to enhance peritoneal cell counts. When these Quercetin-3-O-Î²-Glucoside treated animals underwent i.p. inoculation with DAL cells, tumour cell growth was found to be inhibited. After 14 days of inoculation, Quercetin-3-O-Î²-Glucoside is able to reverse the changes in the haematological parameters, protein and PCV consequent to tumour inoculation.
Keywords: Daltonâ€™s Ascitic Lymphoma, Quercetin-3-O-?-Glucoside, Mean Survival time, Haematological parameters, Cansjera rheedii.
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