DESIGN, FORMULATION AND EVALUATION OF GUAIPHENESIN SUSTAINED RELEASE TABLETS
Bharathi Arigela*, Harika Cherukuri and Chandra Sekhar Naik D.
Guaiphenesin (GUA) is a weakly basic drug and used as an expectorant. The half -life of Guaiphenesin is 1hour and generally administered as immediate release tablet at a dose of 200-400mg every 4 to 6 hours. The main objective of research work was to develop once daily extended release tablets of Guaiphenesin by both wet granulation and direct compression techniques and to compare the in-vitro dissolution profiles with the domestic reference product. We evaluated all the physicochemical parameters like drug content, bulk density, tapped density, compressibility, weight variation, hardness, friability and dissolution method. They followed zero order and first order effect. The optimized formulation F12 showed the higher cumulative drug percent release compared to other formulations. Solubility showed that the drug is more soluble in acidic medium. The in-vitro release of Guaiphenesin extended release tablets were studied in 900ml of 0.1N HCL for 12hrs was used as dissolution medium using USP type I dissolution apparatus at 37±2oC and 75rpm speed.
Keywords: Drug name, sustained release, Carbopol 934P NF, HPMC polymers.
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