SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING AND ANTI-BACTERIAL ACTIVITY OF 2,3-DISUBSTITUTED QUINAZOLIN-4(3H)-ONES
V. Rajendiran*, K.Girija
A series of some novel 2,3-disubstituted quinazolin-4(3H) ones were synthesized by condensing 2-substituted-4H-3,1-Benzoxazin-4-one with Lamivudine to yield the title compounds. The starting material 2-substituted-4H-3,1-Benzoxazin-4-one was synthesized from anthranilic acid and substituted benzoyl chloride. The structures of the synthesized compounds were confirmed by FT-IR, 1H NMR, Mass and Elemental Analysis. Docking study of the synthesized compounds were carried out by Auto Dock software using Biotin Carboxylase as Target Protein. The Synthesized compounds were screened for their in- vitro anti-bacterial activity.
Keywords: Quinazolinone, Lamivudine, Biotin Carboxylase, Anti-bacterial activity.
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