URINARY TRACT INFECTION: A STUDY OF DRUG USE EVALUATION IN A TERTIARY CARE TEACHING HOSPITAL
Shrishailgouda S. Patil*, Anu P. Venu and H. Doddayya
Objective: The objective of the present study is to carry out drug utilization evaluation in urinary tract infections with an aim to ensure appropriate, safe and effective use of antibiotics thereby reducing patient treatment costs and also to prevent antimicrobial resistance. Materials & Methods: A prospective observational study was carried out for a total of 105 in-patients diagnosed with UTI in the in-patient department of General medicine of Navodaya Medical College Hospital & Research Centre, Raichur. The drug therapy was reviewed and the relevant information was recorded in a structured proforma & data was evaluated by comparing with standard IDSA guidelines for Infectious diseases. Results: The results of the study revealed that the incidence of urinary tract infections was more in females (65.72%) compared to males (34.28%) and more common in the age group between 30-40 years (30.47%). Majority of the UTI cases were found to be uncomplicated (84.77%) than the complicated (15.23%). The rank order of antibiotics prescribed was as follows:fluroquinolones>cephalosporins>nitrofurantoin>aminoglycosides>penicillin. Among 105 patients, deviation in the line of treatment has been observed in a total of 57 patients (54.28%) which accounts for both complicated and uncomplicated UTI patients. Higher incidence of deviation was observed for the uncomplicated UTI (n=50, 58.13%) compare to complicated UTI (n=07, 43.75%). Conclusion: The results of the study conclusively suggested the deviation in the line of treatment for more than 50%of the study population which necessitates the need to improve the awareness among the physicians to use the recommendations of IDSA guidelines in the treatment of UTI for the better therapeutic outcome and also to reduce the antibiotic resistance.
Keywords: Drug utilization evaluation; Urinary tract infections; Antibiotics, IDSA guidelines; Antimicrobial resistance.
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