EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

TOXIC EFFECTS OF INDUCED SODIUM ARSENITE ON THE OVARY OF SWISS ALBINO MICE

*Shailendra Kumar and Preety Sinha

ABSTRACT

Arsenic is an environmental pollutant, which can damage reproductive health and causes disruption of the ovary, quality of ova, decreased ova production and infertility in mice and human. Arsenic creates more and more reactive oxygen species (ROS) in the ovary. The present work provides a detailed analysis of contamination of arsenic in Bihar and further may help to check the main root causes of cancer. Female Swiss albino mice (Mus musculus) were selected as the experimental animals. In the treatment group 1.8 mg/kg body weight sodium arsenite and in control group distilled water was given orally by gavage method daily for8 weeks. After the treatment mice were sacrificed and the ovary and blood samples were collected. The effects were assessed by estimating blood arsenic level, serum CA 125 level, LPO level, antioxidant enzymes activity, the apoptotic index in % and histopathological parameters. Sodium arsenite treated group showed no effects on CA 125 in mice blood, LPO level was significantly (p < 0.0001) increased, whereas antioxidant enzymes (SOD & CAT) activity were significantly (p < 0.0001 & p < 0.01) decreased as compared to the control group. Apoptotic index was significantly (p < 0.0001) higher in arsenic treated mice compared with control. Sodium arsenite treated group showed vacuolized corpus luteum and ruptured germinal epithelium with Graafian follicle in comparison with the histology of control mice ovary. Our results suggest that sodium arsenite toxicity adversely affected cells of the ovary; caused DNA damage and altered the oxidative stress along with antioxidant enzymes.

Keywords: Sodium arsenite, Ovary, Oxidative stress, Antioxidant enzymes, Apoptosis, Histopathology.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)