EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

COMPARATIVE EFFICASY OF MAGNESIUM SULPHATE AND CLONIDINE AS AN ADJUVANT TO LIGNOCAINE IN INTRAVENOUS REGIONAL ANAESTHESIA FOR INTRAOPERATIVE AND POSTOPERATIVE ANALGESIA

U. K. Bhagat, Dr. U. S. Gupta*, Mayur Gupta and Palak Chavda

ABSTRACT

Objectives: Intravenous regional anesthesia is used for short procedures for hand and upper limb surgeries. IVRA with adjuvants like opioids, muscle relaxants, NSAIDS increases the efficacy in terms of analgesic duration and quality of anesthesia. We conducted this comparative study for evaluating the effect of adding magnesium sulphate and clonidine with lignocaine in IVRA for upper limb surgeries. Methodology: Seventy five patients ASA class 1 and 2 of either sex, age 18-60 years undergoing upper limbs surgeries were enrolled. They were divided into three groups (25 each) according to drug received. Group L: 9 ml of 2% lignocaine (preservative free) diluted with normal saline to make a total volume of 36 ml of 0.5% lignocaine. Group M: 3 ml of 50% magnesium sulphate with 9 ml of 2 % lignocaine diluted with normal saline to make a total volume of 36 ml, 0.5% lignocaine. Group C: 1 μg/kg clonidine with 9 ml of 2% lignocaine diluted with normal saline to make a total volume of 36 ml of 0.5% lignocaine. Sensory and motor block (onset and recovery time), intraoperative tourniquet pain, time to first tramadol requirement and mean tramadol dosage, quality of operative conditions, hemodynamic parameters, postoperative pain (VAS) scores were recorded. Results: Both groups were comparable in terms of age, sex, ASA grade, baseline hemodynamic parameters, duration of surgery and tourniquet inflation time. Shortened sensory and motor block onset times were established in Group M (p < 0.05). Recovery from sensory and motor blockade was significantly prolonged in Group M (p < 0.05). Anesthesia excellence as determined by anaesthesiologist and the surgeon was significantly better in C group as compared to rest two groups (p < 0.05).There was statistically significant difference (p > 0.05) in intraoperative VAS in Group M and C as compared to Group L, throughout the procedure. Time to First analgesic requirement in Group C 43.04 ± 27.46, Group M 42.72 ± 18.06 and Group L was 27.08 ± 4.45 minutes (p < 0.05). Postoperative VAS scores for 24 hours were higher in Group L as compared to Group M and C (p < 0.05). Conclusion: Magnesium sulphate as an adjuvant to lignocaine hydrochloride for IVRA for upper limb surgeries shorten the onset of sensory and motor block to greater extent as compared to clonidine and lignocaine alone though postoperative analgesia was found to be of longer duration with clonidine as an adjuvant.

Keywords: Biers block; IVRA; Clonidine; Magnesium sulphate; Lignocaine hydrochloride.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)