EFFECT OF CERTAIN POLYMERS ON PHYSICOCHEMICAL PROPERTIES OF TENOXICAM.
Esmat E. Zein, Mohamed A. Ossman, Shaimaa S. Mahmoud* and Heba A. Yassin
Tenoxicam is a widely used non-steroidal anti-inflammatory drug (NSAID). It is practically insoluble in water 14.1mg/ml, it is sparingly soluble in methylene chloride, very slightly soluble in ethanol and dissolves in solutions of acids and alkalis. The work in this study was performed in order to investigate the effect of certain polymers (Eudragit RL100, EudragitRS100 and methyl cellulose) in different drug to polymer ratios on the dissolution of tenoxicam in acidic as well as alkaline pH values. Solid dispersion technique was the technique of choice for preparing microbeads. FT-IR and X-ray diffraction were performed in order to investigate the interaction - if any- between the drug and the polymers.
Keywords: Tenoxicam, Eudragit RL100, Eudragit RS100, methyl cellulose, solid dispersion.
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