EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

IN VIVO EVALUATION OF ORANGE PEEL OIL AND ITS MAJOR COMPONENT HESPERIDIN AGAINST ENTERAL PHASE OF TRICHINELLA SPIRALIS

Iman Khallaf*, Ragaa Othman, Abeer Mahmoud, Rasha Attia and Omar Tahawy

ABSTRACT

Background: Trichinellosis is widespread zoonosis for which no effective drug treatment is available at this time; anthelmintics such as albendazole are commonly used to treat human trichinellosis, although it is not fully effective. This study was carried out to assess, for the first time, the effect of orange secondary metabolites for treatment of this disease. Objective: In this study the effect of different orange peel components against enteral phase of Trichinella spiralis in mice was evaluated for the first time. This includes: orange oil prepared either by solvent extraction (OIL I), its non-volatile solid residue (OIL IR), or the oil prepared by steam distillation (OIL II) and hesperidin (HSP) Materials and Methods: For each fraction two doses 300 mg/kg and 600 mg/kg were investigated in mice. The effectiveness is compared to mice treated with the common commercial drug albendazole and infected non-treated mice. Results: The least mean adult count was found in group B treated with albendazole (18.0 ± 4.6) with efficacy of 84.6%. All treated groups with 600 mg/kg showed significant increase in the reduction of adult T. spiralis more than the treated groups by 300 mg/kg. The decrease in the mean number of the adult worms was highly significant in all treated groups (p value < 0.001) except group E (I) treated with OIL II at a dose of 300 mg/kg was only significant (p value < 0.05). Conclusion: Orange peel has a significant anti-Trichinella activity. This activity is attributed mainly to its content of hesperidin, OIL I and OIL IR.

Keywords: Enteral phase, Hesperidin, Orange oil, Orange peel, Trichinella spiralis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)