EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

PYRUVATE KINASE ISOFORM M2 AS A DIAGNOSTIC TOOL FOR RENAL CELL CARCINOMA

Ibrahim El Tantawy El Sayed*, Sally Mohammed El-Hefnway, Alshimaa Mahmoud Alhanafy and Khadiga Mohamed Sallam

ABSTRACT

Renal cell carcinoma (RCC) is the most common cancer in the kidney. Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenol pyruvate and ADP to pyruvate and ATP in glycolysis. Aim of the study: The current study was conducted to evaluate pyruvate kinase M2 (PKM2) level in serum as a tumor marker in renal cell carcinoma. Subjects and Methods: serum PKM2 level of 120 patients with RCC and 80 healthy volunteers was detected by ELISA, and correlated with tumor stage and grade. Results: serum PKM2 level was significantly higher in RCC group than in control groups. There was a significant positive correlation between PKM2 and both of tumor stage and grade. ROC curve revealed that, at a cut -off point of (2.27 ng/ml), the sensitivity of PKM2 in diagnosis of renal cancer was 70%, the specificity was 68.27%, and accuracy of the test was 66.46%. Conclusions: Serum PKM2 could be considered as a diagnostic marker for RCC. Highlights  Hypertension and diabetes are risk factors for development of RCC  Serum PKM2 is significantly increased in RCC group when compared to controls.  Serum PKM2 may have a role in RCC staging , helping in clinical evaluation.

Keywords: ELISA-PKM2-RCC-tumor.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)